HHS is often associated with a fluid deficit of 100-200 mL/kg (averaging 9 Liters). Fluid replacement is the absolute priority over insulin initiation.
Verified
Last Review: 2026
| Parameter | Criteria for HHS |
|---|---|
| Plasma Glucose | > 600 mg/dL (33.3 mmol/L) |
| Arterial pH | > 7.30 |
| Serum Bicarbonate | > 18 mEq/L |
| Urine/Serum Ketone | Absent or Small |
| Effective Serum Osmolality | > 320 mOsm/kg |
| Mental Status | Stupor / Coma |
Kitabchi AE et al. • Diabetes Care. 2009;Definitive guide on distinguishing DKA from HHS and management protocols.
Last Comprehensive Review: 2026
Clinical Context
We think this might be relevant to the clinical guidance for HHS Diagnostic Criteria (ADA).
Clinical Context
We think this might be relevant to the clinical guidance for HHS Diagnostic Criteria (ADA).
Clinical Context
We think this might be relevant to the clinical guidance for HHS Diagnostic Criteria (ADA).
