Male Hypogonadism Diagnostic Criteria

Total Testosterone (ng/dL)

LH (mIU/mL)

Note: Testosterone should be measured between 8 AM and 10 AM on two separate occasions to confirm a diagnosis of hypogonadism.

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

When to Screen

Clinical features of androgen deficiency (reduced libido, erectile dysfunction, loss of body hair, depressed mood).

Screening in Type 2 Diabetes, Severe Obesity, or long-term Opioid/Glucocorticoid use.

Evaluating secondary osteoporosis in men.

Pituitary mass or history of sellar surgery/radiation.

How it Works

1. Laboratory Thresholds

The Endocrine Society defines hypogonadism as a persistent Total Testosterone < 300 ng/dL (10.4 nmol/L) measured on at least two separate mornings (before 10 AM) in a fasting state.

2. Differentiation

Feature	Primary (Testicular)	Secondary (Pituitary/Hypothalamic)
Testosterone	Low	Low
LH / FSH	High	Low or "Inappropriately Normal"
Common Causes	Klinefelter syndrome, Trauma, Mumps	Prolactinoma, Weight loss, Opioids, Iron overload

Last Comprehensive Review: 2026

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Male Hypogonadism Diagnostic Criteria

When to Use

When to Screen

How it Works

1. Laboratory Thresholds

2. Differentiation

Clinical Pearls

Free Testosterone

Secondary Screen

The Evidence

Primary Source

Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.

Recent Journal Updates

Male Hypogonadism Diagnostic Criteria

When to Use

When to Screen

How it Works

1. Laboratory Thresholds

2. Differentiation

Clinical Pearls

Free Testosterone

Secondary Screen

The Evidence

Primary Source

Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.

Recent Journal Updates