If hyperprolactinaemia is found in an asymptomatic patient, consider "macroprolactin" (a complex of prolactin and IgG) which is biologically inactive but reacts in assays.
Verified
Last Review: 2026
| Level (ng/mL) | Typical Causes |
|---|---|
| < 25 | Normal Range |
| 25 – 100 | Drugs, Stalk Effect, Hypothyroidism, PCOS, Macroprolactin |
| 100 – 250 | Microprolactinoma, Risperidone, Metoclopramide |
| > 250 | Macroprolactinoma (almost certainly) |
Melmed S et al. • J Clin Endocrinol Metab. 2011;The comprehensive guideline for interpreting prolactin levels and managing prolactinomas.
Last Comprehensive Review: 2026
Clinical Context
We think this might be relevant to the clinical guidance for Prolactin Interpretation Tool.
Clinical Context
We think this might be relevant to the clinical guidance for Prolactin Interpretation Tool.
Clinical Context
We think this might be relevant to the clinical guidance for Prolactin Interpretation Tool.
