Liddle Syndrome is a gain-of-function mutation in ENaC. It mimics hyperaldosteronism clinical features (HTN, hypokalaemia) but aldosterone levels are suppressed. Triamterene/Amiloride are diagnostic and therapeutic.
Verified
Last Review: 2026
| Feature | Primary Aldosteronism | Liddle's Syndrome | Licorice Ingestion |
|---|---|---|---|
| Renin | Suppressed | Suppressed | Suppressed |
| Aldosterone | High | Suppressed | Suppressed |
| Potassium | Low-Normal | Low | Low |
| Treatment | Spironolactone | Amiloride | Stop Licorice |
Warnock DG. • Curr Opin Nephrol Hypertens. 2001;The review detailing the genetics and electrolyte patterns of ENaC overactivity.
Last Comprehensive Review: 2026
Clinical Context
We think this might be relevant to the clinical guidance for Liddle's Syndrome vs. Primary Aldosteronism.
Clinical Context
We think this might be relevant to the clinical guidance for Liddle's Syndrome vs. Primary Aldosteronism.
Clinical Context
We think this might be relevant to the clinical guidance for Liddle's Syndrome vs. Primary Aldosteronism.
