Glucose exerts an osmotic effect that pulls water from cells into the ECF, diluting the sodium concentration. The 1.6 factor is most commonly used for glucose < 400 mg/dL, while 2.4 may be more accurate for more severe elevations.
Verified
Last Review: 2026
Katz MA. • N Engl J Med. 1973;The original paper establishing the 1.6 correction factor logic.
Hillier TA et al. • Am J Med. 1999;The study suggesting 2.4 as a more accurate factor for severe hyperglycaemia.
Last Comprehensive Review: 2026
Clinical Context
We think this might be relevant to the clinical guidance for Corrected Sodium (Hyperglycemia Correction).
Clinical Context
We think this might be relevant to the clinical guidance for Corrected Sodium (Hyperglycemia Correction).
Clinical Context
We think this might be relevant to the clinical guidance for Corrected Sodium (Hyperglycemia Correction).
