CLIF-C AD Score for Acute Decompensation of Cirrhosis (CLIF-C AD)

AD is defined as the acute development of ascites, encephalopathy, hemorrhage, or infection in a patient with cirrhosis. While less severe than ACLF, it still carries significant 90-day mortality (~10-20%).

Traditional scores often underestimate mortality in hospitalized patients because they ignore systemic inflammation. CLIF-C AD incorporates the White Cell Count (WBC), providing a more accurate assessment for the inpatient setting.

The score helps clinicians identify patients who appear stable but are at high risk of rapid deterioration into multi-organ failure (ACLF).