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Clinical Notice:OpiCalc is not a substitute for professional clinical judgment. Always verify dosages and guidelines.

OpiCalc © 2018-2026

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Recent Journal Updates

DiabetologiaJun 6, 2026
Plasma small RNA profiling reveals a three-miRNA signature associated with early beta cell dysfunction across glucose tolerance stages

Clinical Context

We think this might be relevant to the clinical guidance for IOTA Simple Rules.

WHO NewsJun 5, 2026
Africa CDC and WHO launch joint continental Ebola response plan

Clinical Context

We think this might be relevant to the clinical guidance for IOTA Simple Rules.

DiabetologiaJun 5, 2026
MASLD, diabetes and PMOS across the female life stages

Clinical Context

We think this has broad domain relevance to IOTA Simple Rules.

IOTA Simple Rules

IOTA Simple Rules

International Ovarian Tumor Analysis

Benign Features (B-Rules)
Malignant Features (M-Rules)

IOTA Conclusion

INCONCLUSIVE / UNCLASSIFIED

Simple Rules can classify ~75% of masses. Masses that don't fit (neither or both types) should be analyzed using IOTA ADNEX / Specialist assessment.

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

Primary Clinical Uses

Sonographic characterization of adnexal/ovarian masses
Triaging surgical referrals (general gynecology vs. gynecologic oncology)
Standardizing global ultrasound terminology regarding ovarian cysts

Why it Exists

Prior to IOTA, radiologists used highly subjective terminology ("complex", "worrisome", "thickened") that caused massive over-operation by oncologists for universally benign cysts, and accidental rupture of malignant cysts by generalists.

Last Comprehensive Review: 2026