Recent Journal Updates

Drug SafetyJun 2, 2026

Gabapentin and Pregabalin Use in First Trimester of Pregnancy and Risk of Specific Congenital Anomalies: An IMI ConcePTION European Case-Malformed Control Study

Clinical Context

We think this might be relevant to the clinical guidance for Syphilis Management in Pregnancy.

JAMAJun 2, 2026

Syphilis Linked to Higher Risk of Some Cardiovascular Outcomes

Clinical Context

We think this might be relevant to the clinical guidance for Syphilis Management in Pregnancy.

JAMAJun 2, 2026

New Study Finds No Link Between Acetaminophen Use in Pregnancy and Autism

Clinical Context

We think this might be relevant to the clinical guidance for Syphilis Management in Pregnancy.

Syphilis Management

Syphilis in Pregnancy

Screening Protocol

Universal Screening at 1st ANC
RPR / VDRL (Non-treponemal)
TPPA / TPHA (Treponemal Confirm)
Repeat at 28w & Delivery in high-risk

WHO/FIGO Treatment

Benzathine Penicillin G

2.4 Million Units (MU) IM

Congenital Prevention

Goal: Treatment > 30 Days before EDD

Jarisch-Herxheimer reaction risk: Warn patient & monitored especially in late pregnancy due to potential for uterine contractions and fetal distress.

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

When to Screen

Universal screening at the first prenatal visit (required by law in most jurisdictions).

Rescreen at 28 weeks and at delivery for high-risk patients or those in high-prevalence areas.

Evaluation of any patient presenting with an unexplained maculopapular rash (palms/soles) or painless genital ulcer (chancre).

Mandatory workup for all cases of fetal hydrops or unexplained stillbirth.

Diagnosis Requirements

Diagnosis requires two-stage serologic testing: a nontreponemal test (RPR or VDRL) and a treponemal-specific test (TP-PA or FTA-ABS). A single positive test is insufficient due to potential biological false positives.

Last Comprehensive Review: 2026

Recent Journal Updates

Drug SafetyJun 2, 2026

Gabapentin and Pregabalin Use in First Trimester of Pregnancy and Risk of Specific Congenital Anomalies: An IMI ConcePTION European Case-Malformed Control Study

Clinical Context

We think this might be relevant to the clinical guidance for Syphilis Management in Pregnancy.

JAMAJun 2, 2026

Syphilis Linked to Higher Risk of Some Cardiovascular Outcomes

Clinical Context

We think this might be relevant to the clinical guidance for Syphilis Management in Pregnancy.

JAMAJun 2, 2026

New Study Finds No Link Between Acetaminophen Use in Pregnancy and Autism

Clinical Context

We think this might be relevant to the clinical guidance for Syphilis Management in Pregnancy.