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PPH Protocol (FIGO)

Obstetric Shock Index

Visual EBL Reference

Full Kidney Dish≈ 500mL
10x10cm Swab (Soaked)≈ 60mL
Large Inco-pad (Soaked)≈ 250mL
Sanitary Towel (Soaked)≈ 100mL

FIGO PPH Protocol (Updated)

Universal Emergency Response Framework

01

Immediate Actions

  • Help • Oxygen • 2x LBIV
  • Tone/Tissue/Trauma/Thrombin
  • Bimanual Compression
02

Pharmacotherapy

  • OXTY 40 IU INFUSION
  • TXA 1g IV (Within 3h)
03

Refractory Care

Uterine Balloon (UBT) • NASG Garment • Surgery. If Shock Index persists > 1.1 → ACTIVATE MTP.

Guidelines & Evidence

Verified

Last Review: 2026-07-17

When to Use

Definition & Recognition

Cumulative blood loss ≥1,000 mL or blood loss accompanied by signs or symptoms of hypovolemia within 24 hours after the birth process (includes intrapartum loss) regardless of route of delivery.

When to Activate Protocol

Cumulative blood loss >500 mL in vaginal delivery or >1000 mL in Cesarean (Stage 1).
Vital sign instability (HR >110, BP <85/45, O2 sat <95%).
Visible brisk bleeding or boggy uterus unresponsive to initial massage.
Patient symptomatic of hypovolemia (lightheadedness, tachycardia, pallor).

Risk Factors

Tone: Polyhydramnios, macrosomia, multiple gestation, chorioamnionitis.
Tissue: Retained placenta, placenta accreta spectrum.
Trauma: Episiotomy, lacerations, uterine inversion/rupture.
Thrombin: Abruption, preeclampsia, known coagulopathy.

How it Works

The 4 T’s of PPH

Tone (Atony)70–80% of cases
Tissue (Retained products)10% of cases
Trauma (Lacerations/Inversion)20% of cases
Thrombin (Coagulopathy)<1% of cases

First-Line Uterotonics

Oxytocin (Pitocin)10–40 units per 500–1000 mL IV or 10 units IM
Methylergonovine (Methergine)0.2 mg IM (Avoid in HTN/Preeclampsia)
15-methyl PGF2α (Hemabate)250 mcg IM (Avoid in Asthma)
Misoprostol (Cytotec)600–1000 mcg PR, SL, or PO
Tranexamic Acid (TXA)1g IV over 10 min (Best if given within 3 hrs)

Clinical Pearls

Practical Pearls

Quantified Blood Loss (QBL) is superior to visual estimation (EBL), which typically underestimates loss by 30-50%.
Empty the bladder early; a full bladder displaces the uterus and inhibits effective contraction.
Bimanual massage must be maintained continuously while medications are being prepared.
TXA should be administered early in Stage 2 (within 3 hours of birth) as per the WOMAN trial data.

Critical Contraindications

Methergine is absolutely contraindicated in hypertensive disorders (Preeclampsia, Chronic HTN). Hemabate (Carboprost) is contraindicated in patients with reactive airway disease/asthma.

Next Steps

Stage 1: Recognition & Initial Management

01
Quantify blood loss and increase IV fluids.
02
Fundal massage and verify bladder is empty.
03
Administer Oxytocin; consider Methergine if no HTN.
04
Type and Screen 2 units RBCs.

Stage 2: Refractory PPH (Blood Loss <1500 mL)

01
Mobilize PPH team (OB, Anesthesia, Nursing).
02
Administer 2nd/3rd line uterotonics (Hemabate, Misoprostol, TXA).
03
Escalate to bedside ultrasound to rule out retained products.
04
Prepare for intrauterine balloon tamponade (e.g., Bakri).

Stage 3: Massive Hemorrhage (>1500 mL or Instability)

01
Activate Massive Transfusion Protocol (MTP).
02
Move to Operating Room for surgical intervention.
03
Surgical options: B-Lynch suture, uterine artery ligation, or Hysterectomy.

The Evidence

Core Guidelines

Practice Bulletin No. 183: Postpartum Hemorrhage.

ACOG • Obstetrics & Gynecology. 2017;Reaffirmed 2021. Provides the gold-standard algorithm for medical and surgical management in the US.

The WOMAN Trial

Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage.

WOMAN Trial Collaborators • The Lancet. 2017;Demonstrated that TXA reduced death due to bleeding by 31% if given within 3 hours of birth.

AWHONN Safety Bundle

The Association of Women's Health, Obstetric and Neonatal Nurses (AWHONN) emphasizes that standardized unit protocols and drills significantly reduce maternal morbidity.

Origins & History

Development of Modern Protocols

Postpartum hemorrhage remains the leading cause of maternal mortality worldwide. Modern "Stage-Based" protocols were developed to replace the chaotic "reflexive" management of the past with a structured, multidisciplinary approach similar to ACLS.

The CMQCC Influence

The California Maternal Quality Care Collaborative (CMQCC) was instrumental in developing the toolkits that pioneered the use of QBL (Quantified Blood Loss) and standardized PPH carts, which are now global standards.

Last Comprehensive Review: 2026-07-17

In Recent Clinical News

Scanning Medical Journals

No new significant updates or guidelines matching this topic were found today. We will check again soon.