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Rho(D) Dose (K-B)

Kleihauer-Betke guided Rho(D) Dose

Fetal Cells Counted

Total Cells Counted

Standard protocol includes adding one additional dose to the calculated count to account for sampling error.

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

Primary Clinical Uses

Determining the exact number of Rho(D) immune globulin (RhoGAM) vials required for an Rh-negative mother after a massive Fetomaternal Hemorrhage.

Evaluating trauma, placental abruption, or complicated deliveries in Rh-negative patients.

Preventing severe alloimmunization (Hemolytic Disease of the Fetus and Newborn) in future pregnancies.

Why the KB Test?

The standard 300 mcg dose of RhoGAM only neutralizes 30 mL of fetal whole blood. If a massive abruption causes 100 mL of fetal blood to enter maternal circulation, a single vial will fail, leading to catastrophic sensitization.

Last Comprehensive Review: 2026