Standard protocol includes adding one additional dose to the calculated count to account for sampling error.
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Last Review: 2026-07-17
ACOG Practice Bulletin No. 181. • Obstet Gynecol.. 2017;Reaffirms the 5000 mL maternal blood volume estimation and the strict "+1 vial" rounding protocol to ensure a margin of safety.
Last Comprehensive Review: 2026-07-17
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