Recent Journal Updates

British J Clinical PharmacologyJun 26, 2026

Alpha‐lipoic acid as a preventive measure in radiation‐induced oral mucositis in head and neck cancer patients: A randomized controlled study

Clinical Context

We think this has broad domain relevance to Endometrial Thickness.

British J Clinical PharmacologyJun 26, 2026

Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells

Clinical Context

We think this has broad domain relevance to Endometrial Thickness.

CancerJun 19, 2026

Magnetic resonance imaging‐targeted biopsy with index lesion ipsilateral or bilateral systematic biopsy in prostate cancer: A multicenter, paired, noninferiority, observational trial

Clinical Context

We think this has broad domain relevance to Endometrial Thickness.

Endometrial Thickness

Endometrial Thickness Index

Standardized Clinical Cut-offs

Postmenopausal (ACOG/SOGC)

Normal Threshold≤ 4 mm

High negative predictive value for cancer

Suspicious / Action> 4 mm

Requires biopsy/histology if bleeding

Asymptomatic (No PMB)> 11 mm

May require biopsy even without bleeding

Premenopausal Reference

Menstrual Phase2–4 mm

Proliferative Phase4–8 mm

Periovulatory8–11 mm

Secretory Phase7–16 mm

Clinical Ref: For postmenopausal patients, the measurement of endometrial thickness is most accurate when taken in the midline sagittal plane, excluding any small pockets of fluid.

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

Primary Clinical Uses

Triage and risk stratification for postmenopausal bleeding (PMB)

Determining the necessity for invasive endometrial sampling (biopsy or hysteroscopy)

Evaluating asymptomatic thickened endometrium found incidentally on imaging

When NOT to Use

Absolute thickness is a poor standalone screening tool for asymptomatic postmenopausal women. Routine screening for endometrial cancer using ultrasound is explicitly NOT recommended by ACOG or SGO in the absence of bleeding.

Last Comprehensive Review: 2026

Recent Journal Updates

British J Clinical PharmacologyJun 26, 2026

Alpha‐lipoic acid as a preventive measure in radiation‐induced oral mucositis in head and neck cancer patients: A randomized controlled study

Clinical Context

We think this has broad domain relevance to Endometrial Thickness.

British J Clinical PharmacologyJun 26, 2026

Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells

Clinical Context

We think this has broad domain relevance to Endometrial Thickness.

CancerJun 19, 2026

Magnetic resonance imaging‐targeted biopsy with index lesion ipsilateral or bilateral systematic biopsy in prostate cancer: A multicenter, paired, noninferiority, observational trial

Clinical Context

We think this has broad domain relevance to Endometrial Thickness.