A weight loss of at least 5% within 3 months of starting therapy is considered a "success". If this target is not met, the medication should be discontinued or the dose adjusted, as the likelihood of long-term benefit is low.
In Asian populations, lower BMI thresholds may be appropriate due to increased cardiometabolic risk at lower weights. Some societies recommend using ≥ 25 for comorbidities and ≥ 27.5 for obesity diagnosis in these groups.
2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults.
(Type 2 Diabetes, Hypertension, Dyslipidaemia, or OSA)