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Framingham 10-Year Risk

Framingham 10-Year CVD Risk: Predicts risk of first cardiovascular event (CHD, Stroke, PVD, HF) based on the 2008 D'Agostino model.
Guidelines & Evidence

Verified

Last Review: 2026-07-17

When to Use

When to Use

Primary prevention risk assessment for cardiovascular disease (CVD).
Estimating the 10-year risk of developing coronary heart disease (CHD) events (MI and coronary death).
Decision support for blood pressure management and lifestyle interventions.

Target Population

Historically validated in primarily White populations. Best used for adults aged 30–74 years without established CVD or diabetes.

How it Works

Assessed Variables

Age
Total Cholesterol
HDL Cholesterol
Systolic Blood Pressure (and treatment status)
Smoking Status

Risk Categories

< 10%Low Risk
10–20%Intermediate Risk
> 20%High Risk

Clinical Pearls

Legacy vs. Modern Tools

The Framingham Risk Score was the gold standard for decades. However, modern guidelines (AHA/ACC) now prefer the Pooled Cohort Equations (ASCVD Risk) as they include stroke as an endpoint and are better calibrated for diverse populations.

Next Steps

Complementary Calculators

ASCVD Risk — Pooled Cohort Equations (PCE)
QRISK3 CVD Risk
SCORE2 CVD Risk
Friedewald LDL Equation
Martin/Hopkins LDL Calculation

The Evidence

Primary Derivation

Prediction of coronary heart disease using risk factor categories.

Wilson PW et al. • Circulation.. 1998;n=5,345. The foundational paper for the categorical Framingham risk model.

Last Comprehensive Review: 2026-07-17

In Recent Clinical News

Scanning Medical Journals

No new significant updates or guidelines matching this topic were found today. We will check again soon.