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Clinical Notice:OpiCalc is not a substitute for professional clinical judgment. Always verify dosages and guidelines.

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Recent Journal Updates

DiabetologiaJun 6, 2026
Plasma small RNA profiling reveals a three-miRNA signature associated with early beta cell dysfunction across glucose tolerance stages

Clinical Context

We think this has broad domain relevance to QRISK 3.

DiabetologiaJun 5, 2026
MASLD, diabetes and PMOS across the female life stages

Clinical Context

We think this has broad domain relevance to QRISK 3.

Cancer MedicineJun 5, 2026
Bone Marrow Failure Model Mimics Aplastic Anemia Patients: Single‐Cell Landscape of Immune Response Reveals Novel Mechanisms of Immune Imbalance in AA

Clinical Context

We think this has broad domain relevance to QRISK 3.

QRISK3

QRISK3: UK-calibrated 21-variable 10-year CVD risk calculator (NICE endorsed).

Current Smoker
Diabetes
Family Hx of Premature CVD
Atrial Fibrillation
Rheumatoid Arthritis
Guidelines & Evidence

Verified

Last Review: 2026

When to Use

When to Use

Primary prevention CV risk assessment in UK and similar healthcare systems
Adults aged 25–84 years without prior CVD or diabetes
NICE (UK) guideline–endorsed tool for statin decision-making
More comprehensive than Framingham / ASCVD (21 variables)
Accounts for ethnicity, social deprivation, family history, lifestyle factors

Key Features

Includes deprivation (Townsend score) — UK-specific
Ethnicity-adjusted estimates (White, Asian, Afro-Caribbean, Chinese)
Incorporates atrial fibrillation, chronic kidney disease, systemic autoimmune disease
Medications: corticosteroids, hormone replacement therapy, antipsychotics
More granular than ASCVD; often used in UK primary care

Last Comprehensive Review: 2026

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