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Recent Journal Updates

Alzheimers & DementiaJun 8, 2026
Prevalence of high‐risk plasma p‐tau217 levels and 5‐year transition of risk status in 70‐year‐olds

Clinical Context

We think this has broad domain relevance to Martin/Hopkins LDL Calculation.

DiabetologiaJun 5, 2026
Early glycaemic exposure and cancer risk in people with newly diagnosed type 2 diabetes

Clinical Context

We think this has broad domain relevance to Martin/Hopkins LDL Calculation.

Drug SafetyMay 12, 2026
Theoretical Framework and Key Considerations for Time-to-Onset Analysis in Spontaneous Reporting Systems

Clinical Context

We think this might be relevant to the clinical guidance for Martin/Hopkins LDL Calculation.

Martin/Hopkins LDL

Martin/Hopkins LDL: Improved LDL estimation with adjusted TG:VLDL ratio, especially accurate at low triglycerides.

Formula

VLDL = TG / adjusted_divisor
LDL = TC − HDL − VLDL

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

When to Use

LDL calculation when triglycerides <400 mg/dL
Particularly useful when TG <150 mg/dL (superior to Friedewald)
Fine-tuning of dyslipidaemia assessment
Research-grade lipid analysis; evolving clinical adoption

Advantages Over Friedewald

Adjustable TG:VLDL ratio based on TG levels (not fixed 5:1)
More accurate at low triglycerides (<150 mg/dL)
Better prediction of cardiovascular risk in lean phenotypes
Particularly useful in HFpEF and diabetes populations

Last Comprehensive Review: 2026

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

When to Use

LDL calculation when triglycerides <400 mg/dL
Particularly useful when TG <150 mg/dL (superior to Friedewald)
Fine-tuning of dyslipidaemia assessment
Research-grade lipid analysis; evolving clinical adoption

Advantages Over Friedewald

Adjustable TG:VLDL ratio based on TG levels (not fixed 5:1)
More accurate at low triglycerides (<150 mg/dL)
Better prediction of cardiovascular risk in lean phenotypes
Particularly useful in HFpEF and diabetes populations

Last Comprehensive Review: 2026

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EHMRG
GWTG-HF Score
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