ABC-AF Stroke Score

The ABC-AF Stroke score consistently outperforms clinical-only scores. In derivation cohorts, it achieved a C-index of 0.68 vs. 0.62 for CHA2DS2-VASc (P < 0.001). This superiority is maintained even in primary prevention (patients with no prior stroke).

The ABC-AF framework was developed by Ziad Hijazi and colleagues at the Uppsala Clinical Research Center (Sweden). It moved stroke prevention away from categorical "yes/no" diagnoses toward a continuous physiological model based on myocyte stress and injury.

The development and validation were conducted in strict adherence to the TRIPOD statement for multivariable prediction models, ensuring high-quality evidence for implementation in clinical care.