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Clinical Notice:OpiCalc is not a substitute for professional clinical judgment. Always verify dosages and guidelines.

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Recent Journal Updates

DiabetologiaJun 6, 2026
Plasma small RNA profiling reveals a three-miRNA signature associated with early beta cell dysfunction across glucose tolerance stages

Clinical Context

We think this has broad domain relevance to SCORE 2.

DiabetologiaJun 5, 2026
MASLD, diabetes and PMOS across the female life stages

Clinical Context

We think this has broad domain relevance to SCORE 2.

Cancer MedicineJun 5, 2026
Bone Marrow Failure Model Mimics Aplastic Anemia Patients: Single‐Cell Landscape of Immune Response Reveals Novel Mechanisms of Immune Imbalance in AA

Clinical Context

We think this has broad domain relevance to SCORE 2.

SCORE2

SCORE2: ESC 2021 10-year fatal and non-fatal CVD risk calculator for European primary prevention.

Current Smoker
Diabetes Mellitus
Region
Guidelines & Evidence

Verified

Last Review: 2026

When to Use

When to Use

Primary prevention in European and high-income populations
Adults aged 40–69 without prior CVD, diabetes, CKD
Risk-based therapeutic decision-making (blood pressure, lipids)
ESC 2021 guideline–endorsed tool; preferred over SCORE1
Estimates 10-year fatal + non-fatal CVD events (unlike SCORE1)

Key Advantages

Incorporates non-fatal MI and stroke (20–30% of events)
Updated calibration for contemporary European data
Accounts for region-specific CVD mortality variation
Superior to original SCORE1 for modern risk quantification

Last Comprehensive Review: 2026

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