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Friedewald LDL Equation

Friedewald LDL Equation: Estimates LDL cholesterol from standard lipid panel measurements (Total Cholesterol, HDL, and Triglycerides).

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

When to Use

To estimate Low-Density Lipoprotein (LDL) cholesterol when a direct LDL measurement is not available (which is the standard in most clinical laboratories).

Do Not Use If

Triglycerides are severely elevated (>400 mg/dL or >4.5 mmol/L). The formula assumes a fixed ratio of triglycerides to VLDL cholesterol, which breaks down entirely in severe hypertriglyceridemia.

Last Comprehensive Review: 2026

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

When to Use

To estimate Low-Density Lipoprotein (LDL) cholesterol when a direct LDL measurement is not available (which is the standard in most clinical laboratories).

Do Not Use If

Triglycerides are severely elevated (>400 mg/dL or >4.5 mmol/L). The formula assumes a fixed ratio of triglycerides to VLDL cholesterol, which breaks down entirely in severe hypertriglyceridemia.

Last Comprehensive Review: 2026

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