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Clinical Notice:Calculations must be re-checked and should not be used alone to guide patient care, nor should they substitute for professional clinical judgment. OpiCalc is an auxiliary reference tool for qualified healthcare professionals.

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Recent Journal Updates

WHO NewsApr 24, 2026
Largest catch-up initiative delivers over 100 million childhood vaccinations

Clinical Context

We think this has broad domain relevance to Martin/Hopkins LDL Calculation.

DiabetologiaApr 24, 2026
Updated glucose management indicator (GMI) better aligns with HbA<sub>1c</sub> than current GMI: implications for clinical practice and reporting

Clinical Context

We think this has broad domain relevance to Martin/Hopkins LDL Calculation.

WHO NewsApr 23, 2026
WHO reports measurable health impact in 2025 amid transition to new strategy

Clinical Context

We think this has broad domain relevance to Martin/Hopkins LDL Calculation.

Martin/Hopkins LDL

Martin/Hopkins LDL: Improved LDL estimation with adjusted TG:VLDL ratio, especially accurate at low triglycerides.

Formula

VLDL = TG / adjusted_divisor
LDL = TC − HDL − VLDL

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

When to Use

LDL calculation when triglycerides <400 mg/dL
Particularly useful when TG <150 mg/dL (superior to Friedewald)
Fine-tuning of dyslipidaemia assessment
Research-grade lipid analysis; evolving clinical adoption

Advantages Over Friedewald

Adjustable TG:VLDL ratio based on TG levels (not fixed 5:1)
More accurate at low triglycerides (<150 mg/dL)
Better prediction of cardiovascular risk in lean phenotypes
Particularly useful in HFpEF and diabetes populations

Last Comprehensive Review: 2026

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

When to Use

LDL calculation when triglycerides <400 mg/dL
Particularly useful when TG <150 mg/dL (superior to Friedewald)
Fine-tuning of dyslipidaemia assessment
Research-grade lipid analysis; evolving clinical adoption

Advantages Over Friedewald

Adjustable TG:VLDL ratio based on TG levels (not fixed 5:1)
More accurate at low triglycerides (<150 mg/dL)
Better prediction of cardiovascular risk in lean phenotypes
Particularly useful in HFpEF and diabetes populations

Last Comprehensive Review: 2026

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EHMRG
GWTG-HF Score
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