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Typically < 24 hours.

Clinical Notice:Calculations must be re-checked and should not be used alone to guide patient care, nor should they substitute for professional clinical judgment. OpiCalc is an auxiliary reference tool for qualified healthcare professionals.

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Recent Journal Updates

DiabetologiaMay 7, 2026
Human pancreatic ductal cells from non-diabetic donors function as non-professional antigen-presenting cells upon inflammatory cytokine exposure

Clinical Context

We think this might be relevant to the clinical guidance for REVEAL 2.0 Risk Score.

Tropical Med & Intl HealthMay 5, 2026
Arbovirus Outbreak Reveals Co‐Infection of Dengue and Chikungunya Viruses at Zona da Mata Region in Minas Gerais, Brazil, During 2024

Clinical Context

We think this might be relevant to the clinical guidance for REVEAL 2.0 Risk Score.

British J HaematologyMay 3, 2026
Integrated proteomic and metabolomic profiling reveals sex‐stratified biomarkers predicting chronicity in paediatric primary immune thrombocytopenia

Clinical Context

We think this might be relevant to the clinical guidance for REVEAL 2.0 Risk Score.

REVEAL 2.0 Score

REVEAL 2.0 Clinical Assessment

Validated for WHO Group 1 PAH. Goal-directed therapy targets a Low Risk (≤6) status.

Etiology & History

REVEAL Lite Zone

Clinical & Functional

0
0

Invasive & Diagnostics

DLCO % Predicted
0
Mean RAP (mmHg)
0
PVR (Wood units)
0

Ready for Assessment

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

Primary Clinical Uses

Predict 1-year and 5-year mortality risk in patients with Pulmonary Arterial Hypertension (PAH)
Guide treatment escalation decisions with goal of achieving or maintaining low-risk status
Monitor treatment response at follow-up assessments (recommended every 3-6 months)
Risk stratify patients with inoperable or persistent/recurrent CTEPH (post hoc validation)

Key Clinical Context

The REVEAL 2.0 score demonstrates greater risk discrimination (c-statistic 0.73-0.76) than COMPERA (0.62) or French registry (0.64) strategies. However, in patients with PH secondary to left heart disease (WHO Group 2), the score accurately predicts high-risk outcomes but may not differentiate intermediate from low risk.

Last Comprehensive Review: 2026

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INTERCHEST Score
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