WHO/ICC 2022Integrated AML Classification Framework
Defining Fusions
Defining Mutations & Features
Awaiting Profile
WHO 2022 / ICC 2022 guidelines prioritize molecular defining fusions and mutations over morphology.
Hierarchy Highlights
- Defining fusions override morphology
- NPM1/CEBPA define favorable groups
- TP53 defines high-risk biologic group
Guidelines & Evidence
Verified
Last Review: 2026
Last Comprehensive Review: 2026
