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WHO 2022 / ICC 2022 AML

WHO/ICC 2022Integrated AML Classification Framework

Defining Fusions

Defining Mutations & Features

Awaiting Profile

WHO 2022 / ICC 2022 guidelines prioritize molecular defining fusions and mutations over morphology.

Hierarchy Highlights

  • Defining fusions override morphology
  • NPM1/CEBPA define favorable groups
  • TP53 defines high-risk biologic group
Guidelines & Evidence

Verified

Last Review: 2026

When to Use

Clinical Use

Diagnosing and classifying Acute Myeloid Leukemia (AML) at the time of bone marrow biopsy.
Identifying patients who qualify for AML-directed therapy despite having "low" blast counts (10-19%).
Distinguishing between AML with defining genetic abnormalities versus AML, NOS.

Related Scores in Practice

In clinical practice, this assessment is frequently evaluated alongside other validated measures. Depending on the patient's presentation and specific diagnostic requirements, you may also need to utilize the ELN 2022 AML Risk Classification, WHO 2021 CNS Class. or the MRD Assessment Threshold Interpreter to formulate a comprehensive care plan.

Last Comprehensive Review: 2026

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