MSI / MMRTesting Interpretation Framework
Laboratory Findings
Clinical pearl
IHC (for MMR proteins) and PCR/NGS (for MSI) are complementary. A deficiency in any of the four MMR proteins (MLH1, MSH2, MSH6, PMS2) typically defines dMMR.
Guidelines & Evidence
Verified
Last Review: 2026
Last Comprehensive Review: 2026
