Fleischner 2017 Guidelines

Pure ground-glass nodules (GGN) < 6 mm require no follow-up. For those ≥ 6 mm, the guidelines recommend a follow-up at 6-12 months and then every 2 years for 5 years, as these lesions represent slow-growing indolent adenocarcinomas (AIS/MIA).

High-risk patients include heavy smokers, those with a family history of lung cancer, or those with suspicious nodule morphology (e.g., spiculation). These patients require more aggressive longitudinal surveillance.