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SLiM-CRAB Criteria

Myeloma & MPN

Treatment-triggering myeloma-defining event framework.

Waiting For Required Inputs

Complete the required fields to generate the oncology interpretation.

Guidelines & Evidence

Clinical Details

Section 1

When to Use

Primary Use

Treatment-triggering myeloma-defining event framework.
Section 2

Formula & Logic

Clinical Inputs

HypercalcemiaBinary clinical feature
Renal dysfunction attributable to myelomaBinary clinical feature
Anemia attributable to myelomaBinary clinical feature
One or more lytic bone lesionsBinary clinical feature
Bone marrow plasma cells%
Involved/uninvolved FLC ratioNumeric entry
MRI focal lesionsNumeric entry
Section 3

Pearls/Pitfalls

Result Bands

Section 4

Next Steps

Suggested Next Steps

01
Interpret the result in the full disease-specific clinical context.
02
Correlate with pathology, imaging, performance status, and multidisciplinary guidance.
Section 5

Evidence Appraisal

Evidence Base

Treatment-triggering myeloma-defining event framework.

OpiCalc Medical Oncology Module • Myeloma & MPN. 2026;Logic implemented from widely used contemporary oncology classification, prognostic, and response-assessment frameworks.

Section 6

Literature

Context

SLiM-CRAB Criteria is included in the oncology module as a structured decision-support tool for myeloma & mpn workflows.

Last Comprehensive Review: 2026

Related Oncology Tools

iwCLL 2018 Response
WHO 2022 / ICC 2022 AML
ELN 2022 Risk
IPSS-M
MRD Assessment Framework
CML ELTS Score
ELN CML Milestones
Lugano Classification
NCCN-IPI
MIPI-b
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