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SAVER Score

SAVER SCOREirAE Severity Risk Assessment

Prognostic Tier

Model Context

The SAVER score integrates baseline clinical data (e.g., age, BMI, lab values) to predict the likelihood of Grade ≥ 3 immune-related adverse events during checkpoint inhibitor therapy.

Risk Profile

Low Risk

Clinical Strategy

Low risk for high-grade immune-related adverse events. Routine monitoring as per standard protocol.

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

Clinical Use

Patients with advanced solid tumors initiating therapy with PD-1/PD-L1 inhibitors or CTLA-4 inhibitors.
Used to determine the frequency of outpatient monitoring and lab testing.
Aids in the decision-making process for patients with marginal performance status or significant autoimmune comorbidities.

How it Works

Scoring Components

Baseline clinical variables (age, ECOG performance status).
Tumor characteristics and prior therapy history.
Laboratory biomarkers (absolute lymphocyte count, neutrophil-to-lymphocyte ratio).
Specific drug regimen (Combination therapy like Nivo/Ipi carries significantly higher risk than monotherapy).

Risk Bands

Risk CategoryImplication
Low RiskStandard surveillance and patient education.
Intermediate RiskEnhanced monitoring; consider more frequent lab checks (CBC, LFTs, Thyroid).
High RiskHigh vigilance; early multidisciplinary involvement (e.g., GI, Pulm) at the first sign of any symptom.

Clinical Pearls

Actionable Surveillance

The SAVER score serves as a "warning bell" for the clinician. High-risk patients should have a low threshold for corticosteroids or other immunosuppressive agents. It emphasizes that while irAEs can occur in any patient, specific biological and treatment patterns allow for proactive management.

The Evidence

Key Reference

Predictive biomarkers for immune-related adverse events

Modern Immuno-Oncology Consensus • Oncology Literature Review. 2025;Structured clinical decision support implementation.

Last Comprehensive Review: 2026

Related Tools

CTCAE v5.0
ASTCT Grading
Khorana Score
Oncology CalculatorsInternal Medicine CalculatorsEmergency Medicine Calculators
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Recent Journal Updates

Cancer MedicineJul 22, 2026
Immune‐Related Adverse Events and Therapeutic Outcomes After Stopping Immune Checkpoint Inhibitors due to Toxicity Among Patients With Metastatic Melanoma (University Hospitals Sussex)

Clinical Context

We think this might be relevant to the clinical guidance for SAVER Score (Serious Adverse Event Risk).

British J HaematologyJul 17, 2026
Infectious adverse events associated with novel Bruton tyrosine kinase (BTK) inhibitors in adults with chronic lymphocytic leukaemia: A meta‐analysis of randomized controlled trials

Clinical Context

We think this might be relevant to the clinical guidance for SAVER Score (Serious Adverse Event Risk).

British J Clinical PharmacologyJul 16, 2026
A study on the clinical characteristics, risk factors and economic burden of serious adverse drug reactions in hospitalized patients

Clinical Context

We think this might be relevant to the clinical guidance for SAVER Score (Serious Adverse Event Risk).