CML ELTS Score

The ELTS score uses a complex exponential formula. Unlike Sokal, it assigns a higher weight to age and a lower weight to spleen size, reflecting the modern causes of death in CML patients.

The ELTS score is more accurate than the Sokal score at identifying a truly "Low Risk" group that has almost zero probability of dying from CML. This makes it an excellent tool for identifying candidates for eventually attempting Treatment-Free Remission (TFR).

Patients in the "High Risk" ELTS band have a significantly higher risk of progression to accelerated phase or blast crisis. Many experts recommend starting these patients on a 2nd generation TKI (Dasatinib, Nilotinib, or Bosutinib) to achieve deeper, faster molecular responses.