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WHO 2021 CNS Class.

Head, Neck & CNS

Integrated CNS tumor classifier using IDH, 1p/19q, EGFR, chromosome 7/10, CDKN2A/B, and necrosis/MVP patterns.

IDH mutation

1p/19q codeletion

CDKN2A/B homozygous deletion

TERT promoter mutation

EGFR amplification

Combined chromosome +7 / -10 signature

Necrosis or microvascular proliferation

Calculated Interpretation

Diffuse Astrocytoma / Requires Integration

WHO 2021 CNS entities are defined by integrated histologic and molecular criteria.

Guidelines & Evidence

Clinical Details

Section 1

When to Use

Primary Use

Integrated CNS tumor classifier using IDH, 1p/19q, EGFR, chromosome 7/10, CDKN2A/B, and necrosis/MVP patterns.

Section 2

Formula & Logic

Clinical Inputs

IDH mutation	Binary clinical feature
1p/19q codeletion	Binary clinical feature
CDKN2A/B homozygous deletion	Binary clinical feature
TERT promoter mutation	Binary clinical feature
EGFR amplification	Binary clinical feature
Combined chromosome +7 / -10 signature	Binary clinical feature
Necrosis or microvascular proliferation	Binary clinical feature

Section 3

Pearls/Pitfalls

Result Bands

Section 4

Next Steps

Suggested Next Steps

Interpret the result in the full disease-specific clinical context.

Correlate with pathology, imaging, performance status, and multidisciplinary guidance.

Section 5

Evidence Appraisal

Evidence Base

Integrated CNS tumor classifier using IDH, 1p/19q, EGFR, chromosome 7/10, CDKN2A/B, and necrosis/MVP patterns.

OpiCalc Medical Oncology Module • Head, Neck & CNS. 2026;Logic implemented from widely used contemporary oncology classification, prognostic, and response-assessment frameworks.

Section 6

Literature

Context

WHO 2021 CNS Class. is included in the oncology module as a structured decision-support tool for head, neck & cns workflows.

Last Comprehensive Review: 2026

Related Oncology Tools

Have feedback about this calculator?Let us know.

WHO 2021 CNS Class.

Head, Neck & CNS

Integrated CNS tumor classifier using IDH, 1p/19q, EGFR, chromosome 7/10, CDKN2A/B, and necrosis/MVP patterns.

IDH mutation

1p/19q codeletion

CDKN2A/B homozygous deletion

TERT promoter mutation

EGFR amplification

Combined chromosome +7 / -10 signature

Necrosis or microvascular proliferation

Calculated Interpretation

Diffuse Astrocytoma / Requires Integration

WHO 2021 CNS entities are defined by integrated histologic and molecular criteria.

Guidelines & Evidence

Clinical Details

Section 1

When to Use

Primary Use

Integrated CNS tumor classifier using IDH, 1p/19q, EGFR, chromosome 7/10, CDKN2A/B, and necrosis/MVP patterns.

Section 2

Formula & Logic

Clinical Inputs

IDH mutation	Binary clinical feature
1p/19q codeletion	Binary clinical feature
CDKN2A/B homozygous deletion	Binary clinical feature
TERT promoter mutation	Binary clinical feature
EGFR amplification	Binary clinical feature
Combined chromosome +7 / -10 signature	Binary clinical feature
Necrosis or microvascular proliferation	Binary clinical feature

Section 3

Pearls/Pitfalls

Result Bands

Section 4

Next Steps

Suggested Next Steps

Interpret the result in the full disease-specific clinical context.

Correlate with pathology, imaging, performance status, and multidisciplinary guidance.

Section 5

Evidence Appraisal

Evidence Base

Integrated CNS tumor classifier using IDH, 1p/19q, EGFR, chromosome 7/10, CDKN2A/B, and necrosis/MVP patterns.

OpiCalc Medical Oncology Module • Head, Neck & CNS. 2026;Logic implemented from widely used contemporary oncology classification, prognostic, and response-assessment frameworks.

Section 6

Literature

Context

WHO 2021 CNS Class. is included in the oncology module as a structured decision-support tool for head, neck & cns workflows.

Last Comprehensive Review: 2026

Related Oncology Tools

Have feedback about this calculator?Let us know.