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Clinical Notice:OpiCalc is not a substitute for professional clinical judgment. Always verify dosages and guidelines.

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Recent Journal Updates

Intensive Care MedicineJun 8, 2026
International evidence-based recommendations for point-of-care lung ultrasound

Clinical Context

We think this might be relevant to the clinical guidance for CTCAE v5.0 (Common Terminology Criteria).

CancerJun 5, 2026
Executive summary of American Radium Society Appropriate Use Criteria for the treatment of locoregionally recurrent rectal cancer

Clinical Context

We think this might be relevant to the clinical guidance for CTCAE v5.0 (Common Terminology Criteria).

DiabetologiaMay 26, 2026
Clinical and psychological phenotypes of type 1 diabetes and disordered eating derived from a case vignette series: T1DE phenotypes

Clinical Context

We think this might be relevant to the clinical guidance for CTCAE v5.0 (Common Terminology Criteria).

CTCAE v5.0

CTCAE v5.0Common Terminology Criteria for Adverse Events

General Grading Criteria

Note: These are general definitions. For specific organ toxicities (e.g., Pneumonitis, Diarrhea), please refer to the full NCI CTCAE v5.0 dictionary which contains detailed clinical descriptions for each grade.

Clinical Impact

Grade 1

General Definition

Mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated.

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

Clinical Use

Mandatory reporting of toxicities in all oncology clinical trials.
Standardizing documentation in routine oncology practice to track drug safety.
Dictating dose-modification rules (e.g., "Hold drug for Grade 3 toxicity until resolved to Grade 1").

Related Scores in Practice

In clinical practice, this assessment is frequently evaluated alongside other validated measures. Depending on the patient's presentation and specific diagnostic requirements, you may also need to utilize the ASTCT Grading, SAVER Score or the Ecog Status to formulate a comprehensive care plan.

Last Comprehensive Review: 2026

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