CTCAE v5.0Common Terminology Criteria for Adverse Events
Note: These are general definitions. For specific organ toxicities (e.g., Pneumonitis, Diarrhea), please refer to the full NCI CTCAE v5.0 dictionary which contains detailed clinical descriptions for each grade.
Clinical Impact
General Definition
Mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated.
Verified
Last Review: 2026
| Grade | General Definition |
|---|---|
| Grade 1 | Mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated. |
| Grade 2 | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL. |
| Grade 3 | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self care ADL. |
| Grade 4 | Life-threatening consequences; urgent intervention indicated. |
| Grade 5 | Death related to AE. |
National Cancer Institute • U.S. Department of Health and Human Services. 2017;Reference manual for clinical toxicity grading.
Last Comprehensive Review: 2026
Clinical Context
We think this has broad domain relevance to CTCAE v5.0 (Common Terminology Criteria).
Clinical Context
We think this has broad domain relevance to CTCAE v5.0 (Common Terminology Criteria).
Clinical Context
We think this might be relevant to the clinical guidance for CTCAE v5.0 (Common Terminology Criteria).