Logo

OpiCalc

FavoritesSpecialtiesDrugsGuidelinesMost Used

Quick Access

Favorites
Most Used

All Specialties

OpiCalc Logo
Clinical CalculatorsDrugsGuidelines
SpecsDrugsGuides
ALBI Grade (Liver)ASTCT GradingATA Thyroid RiskBCLC 2022 Staging (HCC)BSA (Mosteller)CLL-IPICML ELTS ScoreCNS-IPICTCAE v5.0Calvert FormulaDIPSS-Plus (Myelofibrosis)Deauville ScoreEAU NMIBC RiskECOG Performance StatusELN 2022 Risk (AML)ELN CML MilestonesFIGO 2021 (Ovarian)FIGO 2023 (Endometrial)FLIPI-2Fleischner 2017 GuidelinesFong Clinical Risk ScoreHCT-CI (Sorror Score)HPV/p16 OropharynxIGCCCG Risk (Testicular)IMDC (Heng) CriteriaIMWG Myeloma FrailtyIPSS-M (Molecular MDS)ISUP Grade GroupsKarnofsky Status (KPS)Khorana ScoreLugano ClassificationLung-RADS v2022MIPI-b (Biological)MRD Assessment FrameworkMSI/MMR InterpretationMayo 20/2/20 (SMM)NCCN Prostate RiskNCCN-IPI (DLBCL)NSCLC GPAOncotype DX RecurrenceOpioid EquianalgesicPD-L1 TPS InterpretationPERCIST 2.0PREDICT v3.0Platinum-Free IntervalR2-ISS (Revised 2)RANO 2.0RCB (Residual Cancer Burden)RECIST 1.1ROMA ScoreSAVER ScoreSINS ScoreSLiM-CRAB CriteriaSedlis/Peters CriteriaTNM 8th (Colorectal)TNM 8th Ed (Prognostic)TNM 9th (Nasopharynx)TNM 9th Ed (NSCLC)TNM 9th Ed (SCLC)Tyrer-Cuzick (IBIS v8)WHO 2021 CNS Class.WHO 2022 / ICC 2022 AMLZ0011 EligibilityiRECISTiwCLL 2018 ResponsemRECIST (HCC)mRENAL ScoremrTRG (Rectal MRI)
OpiCalc Logo

OpiCalc

Easy, fast, and private medical tools for clinicians. Always free.

No Login Required
Ready for the Bedside

Resources

About UsEditorial PolicyMedical DisclaimerPrivacy PolicyTerms of UseCookie Policy

Support

Contact Us

Clinical Notice:OpiCalc is not a substitute for professional clinical judgment. Always verify dosages and guidelines.

OpiCalc © 2026

•

All Rights Reserved

ALBI Grade (Liver)

ALBI GRADEAlbumin-Bilirubin Liver Function Index

Laboratory Parameters

Note: The ALBI grade was developed to provide an objective evidence-based alternative to the Child-Pugh score, which includes subjective variables like ascites and encephalopathy.

Awaiting Lab Values

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

Clinical Use

Baseline assessment of liver reserve in patients with newly diagnosed HCC.
Predicting overall survival in patients undergoing liver-directed therapies (TACE, ablation).
Selecting patients for clinical trials where objective liver function measurement is required.

How it Works

The ALBI Equation

ALBI Score = (log10 Bilirubin [μmol/L] * 0.66) + (Albumin [g/L] * -0.085)

Grade Thresholds

GradeScore RangeClinical Status
Grade 1≤ -2.60Good liver function; best candidates for aggressive therapy.
Grade 2> -2.60 to ≤ -1.39Intermediate liver function.
Grade 3> -1.39Poor liver function; high risk of liver failure with intervention.

Clinical Pearls

ALBI vs. Child-Pugh

ALBI has been shown to be more discriminatory than Child-Pugh, particularly within the Child-Pugh A cohort. It can identify a sub-group of "Child-Pugh A" patients with significantly worse outcomes who are often over-treated in standard algorithms.

The "ALBI Shift"

Because ALBI is a continuous score, it can track subtle declines in liver function over multiple cycles of treatment better than the categorical Child-Pugh system, allowing for earlier dose adjustments in systemic therapy.

The Evidence

Key Reference

Assessment of Liver Function in Patients With Hepatocellular Carcinoma: A New Prognostic System (ALBI) Based on Albumin and Bilirubin

Johnson PJ et al. • Journal of Clinical Oncology. 2015;33(6):550-8

Last Comprehensive Review: 2026

In Recent Clinical News

Scanning Medical Journals

No new significant updates or guidelines matching this topic were found today. We will check again soon.