Recent Journal Updates

British J HaematologyJun 5, 2026

Machine learning‐driven investigation on liquid–liquid phase separation‐related prognostic signature in diffuse large B‐cell lymphoma

Clinical Context

We think this might be relevant to the clinical guidance for CNS-IPI (CNS Prognostic Index).

DiabetologiaJun 5, 2026

Early glycaemic exposure and cancer risk in people with newly diagnosed type 2 diabetes

Clinical Context

We think this has broad domain relevance to CNS-IPI (CNS Prognostic Index).

PLOS MedicineJun 2, 2026

Prognostic value of cervical length for spontaneous preterm birth in asymptomatic women with singleton pregnancy: An individual participant data meta-analysis

Clinical Context

We think this might be relevant to the clinical guidance for CNS-IPI (CNS Prognostic Index).

CNS-IPICNS Relapse Risk Stratification

Clinical & Lab Parameters

High-Risk Nodal/Extranodal Sites

Relapse Risk

Low Risk

0Points

Clinical Strategy

Low estimated CNS relapse risk. CNS prophylaxis is typically not recommended.

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

Clinical Use

All patients with newly diagnosed Diffuse Large B-Cell Lymphoma (DLBCL).

To identify patients at high risk (≥ 10% risk) for CNS recurrence.

To guide the decision for prophylactic intrathecal or systemic High-Dose Methotrexate.

Related Scores in Practice

In clinical practice, this assessment is frequently evaluated alongside other validated measures. Depending on the patient's presentation and specific diagnostic requirements, you may also need to utilize the NCCN-IPI, IPSID / Lugano Classification or the CTCAE v5.0 to formulate a comprehensive care plan.

Last Comprehensive Review: 2026

Recent Journal Updates

CNS-IPI

Clinical & Lab Parameters

High-Risk Nodal/Extranodal Sites

Low Risk

When to Use

Clinical Use

Related Scores in Practice

Related Oncology Tools

Recent Journal Updates

CNS-IPI

Clinical & Lab Parameters

High-Risk Nodal/Extranodal Sites

Low Risk

When to Use

Clinical Use

Related Scores in Practice

Related Oncology Tools