R2-ISSSecond Revised International Staging System
Official Myeloma Staging
Note: R2-ISS is a composite score calculated from ISS stage (Beta-2 microglobulin/Albumin), LDH, and high-risk cytogenetics [del(17p), t(4;14), t(14;16), and 1q gain].
Guidelines & Evidence
Verified
Last Review: 2026
Last Comprehensive Review: 2026
