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ALBI Grade (Liver)ASTCT GradingATA Thyroid RiskBCLC 2022 Staging (HCC)BSA (Mosteller)CLL-IPICML ELTS ScoreCNS-IPICTCAE v5.0Calvert FormulaDIPSS-Plus (Myelofibrosis)Deauville ScoreEAU NMIBC RiskECOG Performance StatusELN 2022 Risk (AML)ELN CML MilestonesFIGO 2021 (Ovarian)FIGO 2023 (Endometrial)FLIPI-2Fleischner 2017 GuidelinesFong Clinical Risk ScoreHCT-CI (Sorror Score)HPV/p16 OropharynxIGCCCG Risk (Testicular)IMDC (Heng) CriteriaIMWG Myeloma FrailtyIPSS-M (Molecular MDS)ISUP Grade GroupsKarnofsky Status (KPS)Khorana ScoreLugano ClassificationLung-RADS v2022MIPI-b (Biological)MRD Assessment FrameworkMSI/MMR InterpretationMayo 20/2/20 (SMM)NCCN Prostate RiskNCCN-IPI (DLBCL)NSCLC GPAOncotype DX RecurrenceOpioid EquianalgesicPD-L1 TPS InterpretationPERCIST 2.0PREDICT v3.0Platinum-Free IntervalR2-ISS (Revised 2)RANO 2.0RCB (Residual Cancer Burden)RECIST 1.1ROMA ScoreSAVER ScoreSINS ScoreSLiM-CRAB CriteriaSedlis/Peters CriteriaTNM 8th (Colorectal)TNM 8th Ed (Prognostic)TNM 9th (Nasopharynx)TNM 9th Ed (NSCLC)TNM 9th Ed (SCLC)Tyrer-Cuzick (IBIS v8)WHO 2021 CNS Class.WHO 2022 / ICC 2022 AMLZ0011 EligibilityiRECISTiwCLL 2018 ResponsemRECIST (HCC)mRENAL ScoremrTRG (Rectal MRI)
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Clinical Notice:OpiCalc is not a substitute for professional clinical judgment. Always verify dosages and guidelines.

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Recent Journal Updates

Intensive Care MedicineJun 8, 2026
Is acute respiratory distress syndrome a preventable disease?

Clinical Context

We think this might be relevant to the clinical guidance for ACOSOG Z0011 Trial Eligibility.

CancerJun 4, 2026
Association between hyperphosphatemia and overall survival among patients with advanced urothelial cancer treated with erdafitinib in phase 2/3 clinical trials

Clinical Context

We think this might be relevant to the clinical guidance for ACOSOG Z0011 Trial Eligibility.

JAMAJun 2, 2026
Intravenous Tenecteplase Prior to Endovascular Treatment for Ischemic Stroke

Clinical Context

We think this might be relevant to the clinical guidance for ACOSOG Z0011 Trial Eligibility.

Z0011 Eligibility

Z0011ACOSOG ALND Omission Eligibility

Clinical Criteria Checklist

Clinical pearl

The Z0011 trial demonstrated that for women meeting these specific criteria, addition of ALND did not improve 10-year overall survival or regional recurrence-free survival, but did significantly increase morbidity (lymphedema).

Surgical Guidance

Standard Care (ALND)

Management Strategy

Patient does not meet ACOSOG Z0011 criteria. Axillary lymph node dissection (ALND) is traditionally indicated for positive sentinel nodes.

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

Clinical Use

Applied to patients with early-stage breast cancer who are found to have 1 or 2 positive sentinel lymph nodes during surgery.
Used to decide if the patient can safely omit a completion ALND.
Specifically validated for patients undergoing breast-conserving surgery (lumpectomy) followed by whole-breast irradiation.

Related Scores in Practice

In clinical practice, this assessment is frequently evaluated alongside other validated measures. Depending on the patient's presentation and specific diagnostic requirements, you may also need to utilize the Tyrer-Cuzick (IBIS v8), RCB (Residual Cancer Burden), Oncotype DX Recurrence or the Tnm 8th Ed Breast Prognostic to formulate a comprehensive care plan.

Last Comprehensive Review: 2026

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