Lugano Classification

A Complete Metabolic Response (CMR) is defined by a Deauville score of 1, 2, or 3. The Lugano criteria simplified this by removing the need for a bone marrow biopsy for confirmation of CR if the PET-CT is negative, provided there was no suspicious bone marrow involvement initially.

Lugano standardized the definition of "bulky disease" as a single nodal mass ≥ 10 cm in diameter, or ≥ 1/3 the transthoracic diameter in Hodgkin lymphoma. This is a critical factor in determining whether a patient receives chemotherapy alone or combined modality therapy.