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Clinical Notice:OpiCalc is not a substitute for professional clinical judgment. Always verify dosages and guidelines.

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Recent Journal Updates

CancerJun 8, 2026
Clinicopathologic characteristics of early‐onset breast cancer among unselected young Black women

Clinical Context

We think this has broad domain relevance to ROMA Score (Risk of Ovarian Malignancy Algorithm).

DiabetologiaJun 5, 2026
MASLD, diabetes and PMOS across the female life stages

Clinical Context

We think this might be relevant to the clinical guidance for ROMA Score (Risk of Ovarian Malignancy Algorithm).

WHO NewsMay 31, 2026
Joint statement by the Government of the Democratic Republic of the Congo and WHO concerning the outbreak of Ebola disease caused by the Bundibugyo virus

Clinical Context

We think this has broad domain relevance to ROMA Score (Risk of Ovarian Malignancy Algorithm).

ROMA Score

ROMA SCORERisk of Ovarian Malignancy Algorithm

Clinical & Lab Inputs

pmol/L
U/mL

Clinical pearl

HE4 is less affected by endometriosis or inflammatory conditions compared to CA-125, making the ROMA score more specific than CA-125 alone for detecting epithelial ovarian cancer.

Enter lab values

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

When to Use

In women with a documented pelvic/adnexal mass (detected via physical exam or imaging).
To aid in the triage of patients to either a general obstetrician-gynecologist or a specialized gynecologic oncologist.
Requires the patient's menopausal status, CA-125 level, and HE4 (Human Epididymis Protein 4) level.

Related Scores in Practice

In clinical practice, this assessment is frequently evaluated alongside other validated measures. Depending on the patient's presentation and specific diagnostic requirements, you may also need to utilize the FIGO 2021 (Ovarian) or the Platinum-Free Interval to formulate a comprehensive care plan.

Last Comprehensive Review: 2026

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