Factor Inhibitor Bethesda Titre Interpreter

Low Titre responders who do NOT increase their titre after factor exposure are "Low Responders." Those who jump to high titres (>5 BU) after exposure are "High Responders," even if their baseline titre is currently low.

The Nijmegen modification brings the pH of the test plasma to 7.4 and standardizes protein concentration, improving the specificity of the assay for low-level inhibitors.

Named after the city of Bethesda, Maryland, where the 1974 consensus conference that standardized inhibitor testing was held.