Thalassaemia Transfusion Threshold

Typically every 2–4 weeks using leucodepleted, phenotypically matched RBCs (at minimum C, E, and K matching).

In TDT, waiting for Hb to drop < 7 g/dL can lead to irreversible bone marrow expansion and skeletal deformities. The goal is "Hypertransfusion" (maintaining Hb > 9.5) to keep erythropoietin levels low.

Developed by the TIF to standardize global care, ensuring that even in resource-limited settings, the biological principles of marrow suppression are upheld to prevent long-term morbidity.