SLiM-CRAB Criteria

Historically, CRAB features (end-organ damage) were required to start therapy. The 2014 IMWG update added the SLiM biomarkers because patients with these findings have an ~80% risk of developing CRAB features within 2 years. Treating early prevents irreversible organ damage.

Derived by the International Myeloma Working Group to modernize the 2003 criteria, reflecting improvements in imaging and biochemical assays.