JAK2V617F Allele Burden Interpreter

A very low VAF (< 1-2%) in an otherwise healthy individual might represent Clonal Hematopoiesis of Indeterminate Potential (CHIP) rather than a definitive MPN.

Higher VAF (> 50%) is more common in PV and PMF, often reflecting homozygous mutations due to uniparental disomy. Lower VAF is typically seen in ET.

Discovered simultaneously by four independent groups in 2005. It revolutionized the diagnosis of MPNs, which were previously diagnoses of exclusion.