IWG ITP Response Criteria

ITP Outcome Criteria: Standardized definitions for CR and R. A "Response" suggests the patient is effectively protected from spontaneous severe hemorrhage.

Baseline Plt (× 10⁹/L)

Current Plt (× 10⁹/L)

Guidelines & Evidence

Verified

Last Review: 2026-07-17

When to Use

Defining response to therapy (Steroids, IVIG, TPO-agonists, Rituximab) in patients with ITP.

Monitoring long-term durable response in chronic ITP.

Standardizing clinical trial primary and secondary endpoints.

Timing of Assessment

Initial response is typically assessed at 1 week (Steroids/IVIG). Sustained response should be assessed after cessation of therapy or during maintenance.

How it Works

Response Categories

Category	Platelet Threshold	Bleeding Status
Complete Response (CR)	≥ 100 × 10⁹/L	Absence of bleeding
Response (R)	≥ 30 × 10⁹/L AND 2-fold increase	Absence of bleeding
No Response (NR)	< 30 × 10⁹/L OR < 2-fold increase	Any bleeding

Loss of Response

Platelets < 30 × 10⁹/L

Less than 2-fold increase from baseline

Presence of bleeding symptoms

Last Comprehensive Review: 2026-07-17

In Recent Clinical News

Scanning Medical Journals

No new significant updates or guidelines matching this topic were found today. We will check again soon.

IWG ITP Response Criteria

When to Use

When to Use

Timing of Assessment

How it Works

Response Categories

Loss of Response

Clinical Pearls

Why 100k for CR?

The 'R' Safety Zone

The Evidence

Primary Consensus

Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group.

Origins & History

Terminology

In Recent Clinical News

IWG ITP Response Criteria

When to Use

When to Use

Timing of Assessment

How it Works

Response Categories

Loss of Response

Clinical Pearls

Why 100k for CR?

The 'R' Safety Zone

The Evidence

Primary Consensus

Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group.

Origins & History

Terminology

In Recent Clinical News