MAGIC Biomarker Staging: Predicting Non-Relapse Mortality (NRM) using serum concentrations of ST2 and Reg3α. Note: Formal MAGIC calculation requires specific laboratory standardization.
Marker of systemic inflammation
Marker of GI crypt damage
Verified
Last Review: 2026-07-17
| Biomarker | Significance |
|---|---|
| ST2 | Marker of systemic inflammation and endothelial distress; predictor of steroid-refractory GvHD. |
| Reg3α | Marker of intestinal crypt damage; specific for gastrointestinal GvHD. |
| Stage | Risk Level | 6-month NRM (%) |
|---|---|---|
| 1 | Low Risk | 5 - 10% |
| 2 | Intermediate Risk | 20 - 25% |
| 3 | High Risk | 40 - 50% |
Harris AC et al. • JCI Insight. 2017;2(3):e91530.
View SourceLast Comprehensive Review: 2026-07-17
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