Warfarin IWPC Model: Maintenance dose estimation. Factors like Amiodarone and Genetics (CYP2C9/VKORC1) significantly alter VKA metabolism.
Ancestry / Race
Genomic Integration
Estimated Maintenance Dose
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Last Review: 2026-07-17
| Gene | Genetic Influence on Warfarin |
|---|---|
| VKORC1 | Target of warfarin. G variant requires higher dose; A variant requires lower dose. |
| CYP2C9 | Liver enzyme for metabolism. *2 and *3 variants lead to slow metabolism and require lower doses. |
International Warfarin Pharmacogenetics Consortium (IWPC) • New England Journal of Medicine. 2009;360(8):753-64.
View SourcePirmohamed M et al. • NEJM. 2013;Support for improved time-in-therapeutic-range.
View SourceLast Comprehensive Review: 2026-07-17
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