DOAC Dosing: Guidelines vary by Indication (AF vs. VTE) and Patient Factors. Ensure CrCl is calculated via Cockcroft-Gault for accurate dosing.
1. Select Agent
2. Indication
3. Patient Factors
Standard Registered Dose
Can be taken with or without food.
Verified
Last Review: 2026-07-17
| Criteria | Dose |
|---|---|
| Standard | 5 mg bid |
| If ≥ 2 of: Age ≥ 80, Wt ≤ 60kg, Cr ≥ 1.5 mg/dL | 2.5 mg bid |
| Criteria | Dose |
|---|---|
| CrCl > 50 mL/min | 20 mg qd (with food) |
| CrCl 15 - 50 mL/min | 15 mg qd (with food) |
Granger CB et al. • NEJM. 2011;365(11):981-92.
View SourcePatel MR et al. • NEJM. 2011;365(10):883-91.
View SourceLast Comprehensive Review: 2026-07-17
Clinical Context
We think this might be relevant to the clinical guidance for DOAC Dose Selection & Indication Guide.
Clinical Context
We think this might be relevant to the clinical guidance for DOAC Dose Selection & Indication Guide.
Clinical Context
We think this might be relevant to the clinical guidance for DOAC Dose Selection & Indication Guide.
