Febrile Neutropaenia Risk (MASCC)

Febrile Neutropaenia: Goal is to identify low-risk outpatients (Score ≥ 21). High-risk patients (Score < 21) mandate inpatient IV antibiotics.

1. Burden of Febrile Illness

2. Clinical Modifiers

MASCC Risk Score

5

Risk Class

High Risk

Clinical Guidance

Mandates Inpatient Admission & IV Antibiotics.

Guidelines & Evidence

Verified

Last Review: 2026-07-17

When to Use

Identifying patients with febrile neutropaenia who are at a low risk for medical complications.

Selecting candidates for outpatient antibiotic therapy or early hospital discharge.

Applying to adult oncology patients receiving myelosuppressive chemotherapy.

Temperature Threshold

Febrile neutropaenia is typically defined as a single oral temperature of > 38.3°C (101°F) or > 38.0°C (100.4°F) sustained for one hour, in a patient with an ANC < 500 cells/mm³.

How it Works

Predictor Points (Weighted)

Criterion	Points
Burden of illness: No or mild symptoms	5
Burden of illness: Moderate symptoms	3
No hypotension (SBP > 90 mmHg)	5
No COPD (Chronic Obstructive Pulmonary Disease)	4
Solid tumour OR no previous fungal infection in hematologic malignancy	4
No dehydration	3
Outpatient status at fever onset	3
Age < 60 years	2

Interpretation

≥ 21 points: Low-risk (Likelihood of complications < 6%).

< 21 points: High-risk (Mandates inpatient hospitalization).

Last Comprehensive Review: 2026-07-17

In Recent Clinical News

Scanning Medical Journals

No new significant updates or guidelines matching this topic were found today. We will check again soon.

Febrile Neutropaenia Risk (MASCC)

5

When to Use

When to Use

Temperature Threshold

How it Works

Predictor Points (Weighted)

Interpretation

Clinical Pearls

Symptoms vs. Acuity

Primary Strategy

The Evidence

Primary Strategy

The Multinational Association for Supportive Care in Cancer risk index: A multinational scoring system for identifying low-risk febrile neutropenic cancer patients.

Origins & History

Organization

In Recent Clinical News

Febrile Neutropaenia Risk (MASCC)

5

When to Use

When to Use

Temperature Threshold

How it Works

Predictor Points (Weighted)

Interpretation

Clinical Pearls

Symptoms vs. Acuity

Primary Strategy

The Evidence

Primary Strategy

The Multinational Association for Supportive Care in Cancer risk index: A multinational scoring system for identifying low-risk febrile neutropenic cancer patients.

Origins & History

Organization

In Recent Clinical News