IPSID / Lugano Classification

Historically, "B" indicates constitutional symptoms (Fever, Night Sweats, Weight Loss), while "A" indicates their absence. In the Lugano 2014 updates, A/B persists mainly for Hodgkin Lymphoma; for NHL, clinical symptoms are documented but no longer change the stage I-IV for trial purposes.

Involvement of the spleen is considered nodal involvement for the purposes of staging; thus, splenic disease below the diaphragm in a patient with cervical nodes above the diaphragm is Stage III.

The Lugano classification is the mid-2010s update to the classic Ann Arbor (1971) and Cotswolds (1989) systems, primarily integrating the role of PET imaging and simplifying bone marrow evaluation.