IMWG Myeloma Response: Standardized assessment for Myeloma therapy. Use clinical data and marrow results to determine remission depth.
Myeloma Response Status
Criteria for PR or better not yet met based on selected factors.
Verified
Last Review: 2026-07-17
| Category | Definition |
|---|---|
| sCR (Stringent CR) | CR criteria PLUS normal FLC ratio and absence of clonal cells in marrow by IHC/flow. |
| CR (Complete) | Negative Serum/Urine IFE, disappearance of plasmacytomas, and ≤ 5% marrow plasma cells. |
| VGPR | ≥ 90% reduction in serum M-protein OR urine M-protein < 100 mg/24h. |
| PR (Partial) | ≥ 50% reduction in serum M-protein and ≥ 90% reduction in urine M-protein (or < 200 mg/24h). |
| MR (Minimal) | 25–49% reduction in serum M-protein. |
Kumar S et al. • Lancet Oncology. 2016;17(8):e328-e346.
View SourceLast Comprehensive Review: 2026-07-17
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