PCNSL MSKCC Score

The KPS 70 threshold (roughly equivalent to ECOG 2) is a critical pivot point in neuro-oncology. A patient with KPS < 70 cannot care for themselves, representing significant neurological disability from the tumor.

Developed at Memorial Sloan Kettering Cancer Center (MSKCC). It is often compared to the IELSG score (which includes age, PS, LDH, protein, and deep brain location). The MSKCC score is favored for its simplicity in clinical practice.