ICANS Grading (ASTCT): Combined assessment of the ICE score (encephalopathy) and high-risk neuro findings (seizures, raised ICP).
Calculated Encephalopathy Points
Orientation (4), Naming (3), Commands (1), Writing (1), Attention (1)
ASTCT ICANS Grade
No clinical signs of Immune Effector Cell-Associated Neurotoxicity Syndrome.
Verified
Last Review: 2026-07-17
| Task | Points |
|---|---|
| Orientation (Year, Month, City, Hospital) | 4 |
| Naming (3 objects) | 3 |
| Following Commands (1 task) | 1 |
| Writing (Standard sentence) | 1 |
| Attention (Serial 10s from 100) | 1 |
| Grade | Criteria (Any of) |
|---|---|
| 1 | ICE Score 7 - 9 |
| 2 | ICE Score 3 - 6 |
| 3 | ICE Score 0 - 2 OR Any Seizure (focal) OR Focal neurological deficit |
| 4 | ICE Score 0 (unresponsive) OR Status Epilepticus OR Signs of Elevated ICP (e.g. papilledema) |
Lee DW et al. • Biology of Blood and Marrow Transplantation. 2019;25(4):625-638.
View SourceLast Comprehensive Review: 2026-07-17
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