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Transferrin Saturation Calculator

Transferrin Saturation (TSAT): Direct measure of iron availability for erythropoiesis. Useful for diagnosing iron deficiency and monitoring iron overload conditions.

Serum Iron (µg/dL)

TIBC (µg/dL)

Guidelines & Evidence

Verified

Last Review: 2026-07-17

When to Use

Clinical Use

Screening for iron deficiency anemia.

Initial screening for hereditary hemochromatosis (iron overload).

Monitoring iron status in patients with chronic kidney disease or those on heart failure therapy.

Clinical Pearls

Interpretation

TSAT Value	Interpretation	Considerations
< 20%	Iron Deficiency	Commonly seen in IDA or ACD/IDA mixed picture.
20 - 45%	Normal	Reference range may vary by lab.
> 45% (M) / > 50% (F)	Iron Overload	Screen for Hereditary Hemochromatosis (e.g. C282Y mutation).

Last Comprehensive Review: 2026-07-17