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Fibrinogen Replacement

Fibrinogen Deficit: Calculation based on estimated plasma volume (40 mL/kg). In obstetric emergencies, replacement is typically indicated if fibrinogen is < 2.0 g/L.

Patient weight (kg)

Current Fibrinogen (g/L)

Target Fibrinogen Level (g/L)

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

When to Use

Hypofibrinogenaemia in the context of Massive Haemorrhage (MTP).

Disseminated Intravascular Coagulation (DIC) with bleeding and Fibrinogen < 1.0 g/L.

Obstetric haemorrhage (Targeting higher levels > 2.0 g/L).

Inherited hypofibrinogenaemia.

Target Levels

Clinical Scenario	Target Fibrinogen (g/L)
General Bleeding / DIC	1.0 - 1.5
Obstetric Haemorrhage	2.0 - 2.5
Cardiothoracic Surgery	≥ 1.5
Inherited (Prophylaxis)	≥ 1.0

Last Comprehensive Review: 2026

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