HbS Percentage Target Calculator

The goal of exchange transfusion is not just to increase healthy HbA, but specifically to dilute the concentration of HbS to prevent polymerisation and vaso-occlusion in critical capillary beds.

Automated Red Cell Exchange (aRCE) has the added advantage of being "Iron-Neutral" or even potentially red-cell reducing if the "Isat" (input) and "Outsat" (output) volumes are balanced, unlike simple transfusion which progressively increases iron burden.

Refined through decades of trial and error in exchange transfusion protocols, shifting from "Simple Top-ups" to "Aggressive Dilution" for neurologic protection.